Synthesis of Complex Phenols Enabled by a Rationally Designed Hydroxide Surrogate.
نویسندگان
چکیده
The conversion of aryl halides to phenols under mild reaction conditions is a longstanding and formidable challenge in organic chemistry. Herein, we report the rational design of a broadly applicable Pd-catalyzed method to prepare phenols with benzaldehyde oxime as a hydroxide surrogate. These reactions occur under mildly basic conditions and enable the late-stage hydroxylation of several functionally-dense drug-like aryl halides.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 56 16 شماره
صفحات -
تاریخ انتشار 2017